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Federal Forecasted GRANTS-GOV-360625

The NIDDK Disorders of Gastrointestinal Interoception Consortium Clinical Centers (DGIC)

National Institutes of Health (NIH) · Competitive grant · Science & Technology

At a glance

The NIDDK Disorders of Gastrointestinal Interoception Consortium Clinical Centers (DGIC) is a federal competitive grant from National Institutes of Health for the science & technology sector. Funding: 3000000. Eligible applicants: Small businesses; County governments; State governments; Special district governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); Public housing authorities/Indian housing. Applications are accepted on a rolling basis. Apply via the official listing at www.grants.gov.

Amount
$3M total
Deadline
Rolling
Type
Competitive
Status
Forecasted

About this program

The National Institute of Diabetes and Digestive Diseases and Nutrition (NIDDK) seeks to advance its mission by continuing the work of the NIDDK Gastroparesis Consortium (GpCRC) but also to expand its scope. The collaborative efforts of the GpCRC provided a large database, the Gastroparesis Registry, which is located in the NIDDK central repository and contains information on patients with symptoms of either delayed or normal gastric emptying. It also houses the first U.S. registry of children and adolescents with gastroparesis.  The GpCRC provided clarity and insight that set the stage for transforming our understanding of gastroparesis and laid out a road map for approaching other disorders of gastrointestinal (GI) motility. The findings from clinical studies and trials clearly demonstrated that the clinical burden of gastroparesis is significantly greater than previously realized and involves much more than the stomach. Importantly, the underlying mechanisms remain unclear.   Interoception is the ability of the nervous system to sense, interpret and coordinate signals from various bodily systems including the gastrointestinal tract. Many functional GI disorders are associated with a spectrum of overlapping symptoms including nausea, vomiting, and altered bowel habits all of which involve altered interoceptive signaling. This initiative would broaden the scope beyond gastroparesis to include other adult and pediatric GI conditions associated with impaired interoceptive processing to form a Disorders of Gastrointestinal Interoception Consortium (DGIC).  The consortium may include up to 6 Clinical Research Centers and a Scientific Data Research Center (SDRC, described in a companion notice). There would be an emphasis on multidisciplinary approaches that would reveal the underlying mechanisms that connect GI function (e.g motility) more directly to symptoms, identify disease or response biomarkers that assess treatment efficacy, and leverage state-of-the-art technologies to identify novel therapeutic targets that could be assessed in future clinical trials.   

Who can apply

Small businesses; County governments; State governments; Special district governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); Public housing authorities/Indian housing authorities; For profit organizations other than small businesses; Native American tribal organizations (other than Federally recognized tribal governments); Independent school districts; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Private institutions of higher education; City or township governments; Public and State controlled institutions of higher education; Native American tribal governments (Federally recognized). Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

How to apply

Apply through Grants.gov using funding opportunity number RFA-DK-27-117. Register your organization (SAM.gov + Grants.gov) before the deadline, then submit the application package listed in the official notice.

Apply at official source