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Federal Open GRANTS-GOV-357570

Preclinical Proof of Concept Studies for Rare Diseases (R21 Clinical Trial Not Allowed)

National Institutes of Health (NIH) · Competitive · Science & Technology

At a glance

Preclinical Proof of Concept Studies for Rare Diseases (R21 Clinical Trial Not Allowed) is a federal competitive grant from National Institutes of Health for the science & technology sector. Eligible applicants: Others (see text field entitled "Additional Information on Eligibility" for clarification); Independent school districts; Public housing authorities/Indian housing authorities; Native American tribal organizations (other. The application deadline is July 2, 2027. Apply via the official listing at www.grants.gov.

Amount
See listing
Deadline
Jul 2, 2027
Type
Competitive
Status
Open

About this program

This notice of funding opportunity (NOFO) provides funding to conduct efficacy studies in an established rare disease preclinical model to demonstrate that a proposed therapeutic agent warrants further development. In addition to preclinical efficacy, accompanying pharmacodynamic and pharmacokinetic studies would be supported. Therapeutic agents include small molecules, biologics or biotechnology-derived products. The goal of this NOFO is to spur therapeutic development for a variety of rare diseases by advancing projects to the point where they would attract subsequent investment supporting full Investigational New Drug (IND) application development or progression to clinical trials in the case of repurposing or repositioning.

Who can apply

Others (see text field entitled "Additional Information on Eligibility" for clarification); Independent school districts; Public housing authorities/Indian housing authorities; Native American tribal organizations (other than Federally recognized tribal governments); Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; For profit organizations other than small businesses; State governments; Public and State controlled institutions of higher education; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Private institutions of higher education; County governments; Special district governments; City or township governments; Native American tribal governments (Federally recognized); Small businesses. Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

How to apply

Apply through Grants.gov using funding opportunity number RFA-TR-25-002. Register your organization (SAM.gov + Grants.gov) before the deadline, then submit the application package listed in the official notice.

Apply at official source