At a glance
NINDS Efficacy and Exploratory Clinical Trials (UG3/UH3 - Clinical Trial Required) is a federal competitive grant from National Institutes of Health for the science & technology sector. Eligible applicants: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Native American tribal governments (Federally recognized); Others (see text field entitled "Additional Information on Eligib. The application deadline is March 9, 2029. Apply via the official listing at www.grants.gov.
- Amount
- See listing
- Deadline
- Mar 9, 2029
- Type
- Competitive
- Status
- Open
About this program
This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated clinical trials to the National Institute of Neurological Disorders and Stroke (NINDS). These trials must address questions within the mission and research interests of the NINDS and may include studies of small molecules, biologics, devices as well as surgical, behavioral, diet-based, or rehabilitation therapies. Studies addressing neurological diseases and care across the lifespan are highly encouraged. This notice invites both early- and middle-phase exploratory clinical trials as well as later phase confirmatory Phase 3 or comparative effectiveness clinical trials.
Who can apply
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Native American tribal governments (Federally recognized); Others (see text field entitled "Additional Information on Eligibility" for clarification); Native American tribal organizations (other than Federally recognized tribal governments); Independent school districts; County governments; Public housing authorities/Indian housing authorities; For profit organizations other than small businesses; City or township governments; Special district governments; State governments; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Public and State controlled institutions of higher education; Private institutions of higher education; Small businesses. Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.
How to apply
Apply through Grants.gov using funding opportunity number PAR-27-065. Register your organization (SAM.gov + Grants.gov) before the deadline, then submit the application package listed in the official notice.
Apply at official sourceRelated grants
- NICHD Small Research Grant Program (R03 Clinical Trial Required) NIH · Up to $50K · Jan 7, 2028 Open
- Museum Grants for American Latino History and Culture (2027) IMLS · $5K–$500K · Nov 13, 2026 Open
- Native American Research Centers for Health (NARCH) Planning Grants (R34 - Clinical Trial Not Allowed) NIH · See listing · Jul 7, 2028 Open
- Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional) NIH · See listing · Nov 18, 2026 Open