At a glance
NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required) is a federal competitive grant from National Institutes of Health for the science & technology sector. Eligible applicants: Others (see text field entitled "Additional Information on Eligibility" for clarification); Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; County governments; Independent. The application deadline is January 7, 2028. Apply via the official listing at www.grants.gov.
- Amount
- See listing
- Deadline
- Jan 7, 2028
- Type
- Competitive
- Status
- Open
About this program
The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research. This Parent Notice of Funding Opportunity requires that at least 1 clinical trial be proposed. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.Applicants should note that some ICs (see Related Notices) only accept applications proposing mechanistic studies that meet NIH's definition of a clinical trial through this funding opportunity announcement.
Who can apply
Others (see text field entitled "Additional Information on Eligibility" for clarification); Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; County governments; Independent school districts; City or township governments; Public housing authorities/Indian housing authorities; For profit organizations other than small businesses; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Small businesses; Native American tribal governments (Federally recognized); Special district governments; State governments; Public and State controlled institutions of higher education; Private institutions of higher education; Native American tribal organizations (other than Federally recognized tribal governments). Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
How to apply
Apply through Grants.gov using funding opportunity number PA-25-306. Register your organization (SAM.gov + Grants.gov) before the deadline, then submit the application package listed in the official notice.
Apply at official sourceRelated grants
- NICHD Small Research Grant Program (R03 Clinical Trial Required) NIH · Up to $50K · Jan 7, 2028 Open
- Museum Grants for American Latino History and Culture (2027) IMLS · $5K–$500K · Nov 13, 2026 Open
- Native American Research Centers for Health (NARCH) Planning Grants (R34 - Clinical Trial Not Allowed) NIH · See listing · Jul 7, 2028 Open
- Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional) NIH · See listing · Nov 18, 2026 Open