At a glance
Early Stage Testing of Pharmacologic or Neuromodulatory Device-based Interventions for the Treatment of Mental Disorders (R33- Clinical Trial Required) is a federal competitive grant from National Institutes of Health for the science & technology sector. Eligible applicants: Special district governments; Small businesses; County governments; City or township governments; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Private institutions of hi. The application deadline is October 15, 2027. Apply via the official listing at www.grants.gov.
- Amount
- See listing
- Deadline
- Oct 15, 2027
- Type
- Competitive
- Status
- Open
About this program
NIMH requires an experimental therapeutics approach for the development and testing of therapeutic interventions, in which studies both evaluate the clinical effect of an intervention and generate information about the mechanisms underlying a disorder or an intervention response. As part of NIMHs Clinical Trial Pipeline, this NOFO encourages early stage testing of pharmacologic interventions with novel mechanisms of actions or device-based interventions. More specifically, this NOFO is intended to support early stage testing of pharmacologic or device-based interventions using a protocol design where the presumed mechanism of action of the intervention is adequately tested, to provide meaningful information where target modulation yields a dose-dependent neurophysiological/clinical/behavioral effect.
Who can apply
Special district governments; Small businesses; County governments; City or township governments; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Private institutions of higher education; Independent school districts; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Public and State controlled institutions of higher education; Public housing authorities/Indian housing authorities; For profit organizations other than small businesses; Others (see text field entitled "Additional Information on Eligibility" for clarification); State governments; Native American tribal governments (Federally recognized); Native American tribal organizations (other than Federally recognized tribal governments). Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
How to apply
Apply through Grants.gov using funding opportunity number PAR-25-183. Register your organization (SAM.gov + Grants.gov) before the deadline, then submit the application package listed in the official notice.
Apply at official sourceRelated grants
- Mechanisms that Impact Cancer Risk after Bariatric Surgery (R21 Clinical Trial Not Allowed) NIH · See listing · Jan 7, 2028 Open
- RESTORE Act Direct Component - Non-Construction Activities USDOT · Up to $120.2M · Oct 31, 2026 Open
- Cannabis Research and Innovation Funding Opportunity (RIFO) Department of Fish and Wildlife · Dependant on number of submissions received, application process, etc. · Rolling Open
- Translational Efforts to Advance Gene-based Therapies for Ultra-Rare Neurological and Neuromuscular Disorders (U01 - Clinical Trial Optional) NIH · See listing · Oct 8, 2027 Open