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Federal Closing soon GRANTS-GOV-357180

Cellular and Molecular Biology of Complex Brain Disorders (R21 Clinical Trial Not Allowed)

National Institutes of Health (NIH) · Competitive · Science & Technology

At a glance

Cellular and Molecular Biology of Complex Brain Disorders (R21 Clinical Trial Not Allowed) is a federal competitive grant from National Institutes of Health for the science & technology sector. Eligible applicants: City or township governments; Independent school districts; State governments; For profit organizations other than small businesses; Public housing authorities/Indian housing authorities; Native American tribal organizat. The application deadline is September 7, 2026. Apply via the official listing at www.grants.gov.

Amount
See listing
Deadline
Sep 7, 2026
Type
Competitive
Status
Closing soon

About this program

This Notice of Funding Opportunity (NOFO) encourages research on the biology of high confidence risk factors associated with complex brain disorders, with a focus on the intracellular, transcellular and circuit substrates of neural function. For the purposes of this NOFO, the term complex can refer to a multifactorial contribution to risk (e.g., polygenic and/or environmental) and/or highly distributed functional features of the brain disorder. Studies may be either hypothesis-generating (unbiased discovery) or hypothesis-testing in design and may utilize in vivo, in situ, or in vitro experimental paradigms, e.g., model organisms or human cell-based assays. While behavioral paradigms and outcome measures can be incorporated into the research design to facilitate the characterization of intracellular, transcellular and circuit mechanisms, these are neither required nor expected. Studies should not attempt to model disorders but instead should aim to elucidate the neurobiological impact of individual or combined risk factor(s), such as the affected molecular and cellular components and their relationships within defined biological process(es). This can include the fundamental biology of these factors, components and processes. The resulting paradigms, component pathways and biological processes should be disseminated with sufficient detail to enrich common and/or federated data resources (e.g., those contributing to the Gene Ontology, Synaptic Gene Ontology, FAIR Data Informatics) in order to bridge the gap between disease risk factors, biological mechanism and therapeutic target identification. The present NOFO (R21 activity code) can be used for applications to develop early stage, high-risk, exploratory approaches or establish proof-of-concept where there is little or no preliminary data. Applicants proposing to develop lines of inquiry where feasibility or proof of concept has been established should apply to the companion R01 NOFO (PAR-xx-xxx).

Who can apply

City or township governments; Independent school districts; State governments; For profit organizations other than small businesses; Public housing authorities/Indian housing authorities; Native American tribal organizations (other than Federally recognized tribal governments); Special district governments; Native American tribal governments (Federally recognized); Public and State controlled institutions of higher education; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Private institutions of higher education; Others (see text field entitled "Additional Information on Eligibility" for clarification); County governments; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Small businesses. Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

How to apply

Apply through Grants.gov using funding opportunity number PAR-25-037. Register your organization (SAM.gov + Grants.gov) before the deadline, then submit the application package listed in the official notice.

Apply at official source